Lupus & antiphospholipid syndrome
Quantitative mapping of prefrontal oxygenation dysfunction and neuropsychiatric symptoms in patients with systemic lupus erythematosus: a multichannel functional near-infrared spectroscopy study
Authors' conclusion
Prefrontal HbO oscillation disorder is associated with depressive and anxiety symptoms in SLE patients, and its spatial gradient quantitatively maps the severity of these emotional symptoms during cognitive task engagement
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy controls
- Exposure
- SLE vs healthy controls; SLE subgroups with and without depression or anxiety
- Outcome
- Prefrontal HbO and deoxyhaemoglobin concentrations (activation per channel) during a verbal fluency task
Methodological details37-channel functional near-infrared spectroscopy (fNIRS), verbal fluency task
- 37-channel fNIRS
- Verbal fluency task
Main finding
As reported in the abstract
Prefrontal HbO concentration
- SLE vs healthy controls (HCs): P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbO by anxiety subgroupSLE with anxiety vs HCs | P < 0.05 |
| HbO by anxiety subgroupSLE with anxiety vs SLE without anxiety · more severe HbO decrease on 8 channels | P < 0.05 |
- HbO by anxiety subgroup: more severe HbO decrease on 8 channels (CH6, 10, 13, 17, 18, 24, 25, 26), dorsolateral prefrontal cortex and bilateral frontal pole
HbO by depression subgroup
- SLE with and without depression both showed significantly altered HbO vs HCs across 14 channels (CH6, 9, 10, 13-15, 18, 24-28, 34, 36)
- No significant difference between the two SLE depression subgroups
Original publication
Quantitative mapping of prefrontal oxygenation dysfunction and neuropsychiatric symptoms in patients with systemic lupus erythematosus: a multichannel functional near-infrared spectroscopy study. Lupus Sci Med. Published 1 July 2026. doi:10.
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