Lupus & antiphospholipid syndrome
Depression in systemic lupus erythematosus: A manifestation of microcirculation dysfunction?
Authors' conclusion
This study suggests a possible association between emotional abnormalities and microvascular impairment (cerebral oxygenation and endothelial dysfunction) in SLE
Study context
- Population
- Systemic lupus erythematosus (SLE) patients without a known neuropsychiatric history or treatment with antidepressants or antipsychotic drugs
- Participants
- 23 patients
- Exposure
- SLE patients with depressive symptoms vs without
- Outcome
- Cerebral oxygenation (oxygenated hemoglobin (O2Hb), HHb, total hemoglobin (tHb) by near-infrared spectroscopy (NIRS)) during 3-min handgrip exercise at 30% of maximal strength
- Follow-up
- During exercise
Methodological detailsnear-infrared spectroscopy, handgrip exercise protocol
- Near-infrared spectroscopy
- Handgrip exercise protocol
Main finding
As reported in the abstract
Increase in cerebral O2Hb during exercise
- SLE-depression vs SLE-non-depression: P = 0.039
- SLE-depression vs SLE-non-depression: P = 0.027
Observational data: associations, not effects.
Further findings
Correlation of Beck's Depression Inventory I (BDI-I) score with O2Hb-AUC
- Inverse correlation (rho), p = 0.017
- −0.493
Correlation of BDI-I score with VCAM-1 levels
- Positive correlation (rho), p = 0.034
- 0.501
Original publication
Depression in systemic lupus erythematosus: A manifestation of microcirculation dysfunction? Lupus. Published 29 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →