Lupus & antiphospholipid syndrome
Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus
Authors' conclusion
In our cohort, younger disease SLE onset seems to correlate with a more active immunological profile, while late onset with a higher incidence of comorbidities.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) diagnosed within 12 months, enrolled in the Early Lupus project
- Participants
- 171 patients
- Exposure
- Early onset vs late onset SLE; replicated by age at diagnosis
- Outcome
- Clinical-serological manifestations and comorbidities by age at onset
Methodological detailsEarly Lupus project, baseline and 36-month follow-up
- Early Lupus project
- Baseline and 36-month follow-up
Main finding
As reported in the abstract
Malar rash at baseline
P = 0.042
- Malignancy in medical history in late onset; not recorded in early onset
- 11.4%
Observational data: associations, not effects.
Further findings
| Outcome | Early onset | Late onset | Age at diagnosis 18-45 years | Age at diagnosis >45 years | P value |
|---|---|---|---|---|---|
| Discoid rash at baseline, by age at diagnosisAge at diagnosis >45 years vs Age at diagnosis 18-45 years | — not stated in the abstract | — not stated in the abstract | 6.6% | 18% | P = 0.045 |
| Musculoskeletal involvement, by age at onset · 36 monthsLate onset vs Early onset | 7.3% | 18.6% | — not stated in the abstract | — not stated in the abstract | P = 0.043 |
| Musculoskeletal involvement, by age at diagnosis · 36 monthsAge at diagnosis >45 years vs Age at diagnosis 18-45 years | — not stated in the abstract | — not stated in the abstract | 5.9% | 20.4% | P = 0.009 |
| Renal involvement, by age at diagnosis · 36 monthsAge at diagnosis 18-45 years vs Age at diagnosis >45 years | — not stated in the abstract | — not stated in the abstract | 21.4% | 6.1% | P = 0.03 |
— not stated in the abstract
Damage accrual and new comorbidities · 36 months
- No difference in accumulation of damage, either stratification
- In patients without hypertension and osteoporosis at enrollment, older onset had higher frequency of these comorbidities
Original publication
Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus. Clin Exp Rheumatol. Published 11 October 2021. doi:10.
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