Lupus & antiphospholipid syndrome
Metabolic disturbances in systemic lupus erythematosus evaluated with UPLC-MS/MS
Authors' conclusion
Fatty acid metabolism and phospholipid catabolism were affected in SLE patients.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy controls; serum samples, discovery and validation cohorts
- Comparison
- SLE vs healthy controls; Lupus nephritis (LN) vs SLE without LN
- Outcome
- Serum metabolites differentially expressed in SLE
Methodological detailsdiscovery and validation cohorts, UPLC-MS/MS, multiple reaction monitoring mass spectrometry (MRM-MS) validation, literature review
- Discovery and validation cohorts
- UPLC-MS/MS
- MRM-MS validation
- Literature review
Performance
As reported in the abstract
Significant metabolites identified by UPLC-MS/MS
29
Involved in fatty acid metabolism
20.69%
Involved in phospholipid catabolism
17.24%
Validation cohort: metabolites quantified
11 of 29
Further findings
Literature review
- Decreased amino acids and adenosine in SLE vs healthy controls
- Increased lipids, LDL and VLDL in LN vs healthy controls
Original publication
Metabolic disturbances in systemic lupus erythematosus evaluated with UPLC-MS/MS. Clin Exp Rheumatol. Published 8 July 2021. doi:10.
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