Lupus & antiphospholipid syndrome
Diagnostic implication of left atrial stiffness index in patients with SLE with left ventricular diastolic dysfunction
Authors' conclusion
LASI can effectively reflect changes in LA function in patients with SLE and provide superior diagnostic accuracy compared with other parameters and LA strains for LVDD.
Study context
- Population
- Patients diagnosed with SLE and healthy volunteers145 SLE patients
- Comparison
- Left atrial stiffness index (LASI) vs E/e' average, LA total emptying fraction (LATEF), LASr and LAScd for diagnosing left ventricular diastolic dysfunction (LVDD) in SLE
- Controlsn = 57reference
- Outcome
- Diagnostic performance of LASI for left ventricular diastolic dysfunction (LVDD)
Methodological detailsspeckle tracking echocardiography
- Speckle tracking echocardiography
Performance
As reported in the abstract
Diagnostic performance for LVDD
| Test or model | AUC |
|---|---|
| LASI | 0.919 |
LASI
AUC0.919
Further findings
Left atrial (LA) size, function and LASI in SLE vs controls
- SLE patients: significantly increased LA size, reduced LA function and significantly increased LASI, especially with concomitant lupus nephritis (LN)
Correlates and determinants of LASI
- LASI positively correlated with age, IVSd and E/e' average; negatively with LATEF, LA passive emptying fraction (LAPEF), glomerular filtration rate (GFR), LASr and LAScd
- Independent determinants of LASI (multivariate): age, IVSd, maximum LA size and SLE activity index
Original publication
Diagnostic implication of left atrial stiffness index in patients with SLE with left ventricular diastolic dysfunction. Lupus Sci Med. Published 5 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →