Lupus & antiphospholipid syndrome
2025 American College of Rheumatology ( ACR ) Guideline for the Treatment of Systemic Lupus Erythematosus
Methodological detailsGRADE methodology, systematic literature reviews, PICO format, Voting Panel consensus ≥70% agreement
- GRADE methodology
- Systematic literature reviews
- PICO format
- Voting Panel consensus ≥70% agreement
Recommendations
As issued by the authors
Uniform treatment with HCQ
Limit duration of GC use
Early introduction of conventional and/or biologic immunosuppressive therapies to achieve and maintain control of systemic lupus erythematosus (SLE) inflammation (remission or low disease activity), reduce SLE-related morbidity and mortality, and minimize medication-related toxicities
Original publication
2025 American College of Rheumatology ( ACR ) Guideline for the Treatment of Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 4 November 2025. doi:10.
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