2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis

Sammaritano, LR; Askanase, A; Bermas, BL; Dall'Era, M; Duarte-García, A; Hiraki, LT; Rovin, BH; Son, MBF; Alvarado, A; Aranow, C; Barnado, A; Broder, A; Brunner, HI; Chowdhary, V; Contreras, G; Felix, C; Ferucci, ED; Gibson, KL; Hersh, AO; Izmirly, PM; Kalunian, K; Kamen, D; Rollins, B; Smith, BJ; Thomas, A; Timlin, H; Wallace, DJ; Ward, M; Azzam, M; Bartels, CM; Cunha, JS; DeQuattro, K; Fava, A; Figueroa-Parra, G; Garg, S; Greco, J; Cuéllar-Gutiérrez, MC; Iyer, P; Johannemann, AS; Jorge, A; Kasturi, S; Kawtharany, H; Khawandi, J; Kirou, KA; Legge, A; Liang, KV; Lockwood, MM; Sanchez-Rodriguez, A; Turgunbaev, M; Williams, JN; Turner, AS; Mustafa, RA

doi:10.1002/art.43212

Lupus & antiphospholipid syndrome

2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis

Arthritis RheumatolPublished 7 May 2025Clinical practice guideline

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Methodological detailsGRADE methodology, systematic literature reviews for each PICO question, Voting Panel consensus ≥70%

GRADE methodology
Systematic literature reviews for each PICO question
Voting Panel consensus ≥70%

Recommendations

As issued by the authors

LN therapy is continuous and ongoing, rather than discrete induction/initial and maintenance/subsequent therapies (unifying principle)
Therapy should include pulse GC followed by oral GC taper and two additional immunosuppressive agents for 3-5 years for those achieving complete renal response

Reference

Issued by: American College of Rheumatology (ACR)
Document: Guideline
Scope: Screening, treatment and management of LN; 28 graded recommendations (7 strong, 21 conditional) and 13 ungraded, consensus-based good practice statements

Authors: Sammaritano LR, Askanase A, Bermas BL, Dall'Era M, Duarte-García A, Hiraki LT, et al.
All 52 authors
Sammaritano LR, Askanase A, Bermas BL, Dall'Era M, Duarte-García A, Hiraki LT, Rovin BH, Son MBF, Alvarado A, Aranow C, Barnado A, Broder A, Brunner HI, Chowdhary V, Contreras G, Felix C, Ferucci ED, Gibson KL, Hersh AO, Izmirly PM, Kalunian K, Kamen D, Rollins B, Smith BJ, Thomas A, Timlin H, Wallace DJ, Ward M, Azzam M, Bartels CM, Cunha JS, DeQuattro K, Fava A, Figueroa-Parra G, Garg S, Greco J, Cuéllar-Gutiérrez MC, Iyer P, Johannemann AS, Jorge A, Kasturi S, Kawtharany H, Khawandi J, Kirou KA, Legge A, Liang KV, Lockwood MM, Sanchez-Rodriguez A, Turgunbaev M, Williams JN, Turner AS, Mustafa RA
Journal: Arthritis & Rheumatology
Published: 7 May 2025
DOI: 10.1002/art.43212
PubMed: 40331662

Topic: Lupus & antiphospholipid syndrome

Original publication

2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis. Arthritis Rheumatol. Published 7 May 2025. doi:10.1002/art.43212

Read the original article ↗

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