Lupus & antiphospholipid syndrome
Decreased perforin-producing B cells correlate with systemic lupus erythematosus
Authors' conclusion
These findings revealed that B cells could produce PFP, and a decrease in these cells was associated with SLE pathogenesis.
Study context
- Population
- Peripheral blood of healthy controls and systemic lupus erythematosus (SLE) patients
- Comparison
- SLE patients vs healthy controls
- Outcome
- Frequencies of PFP-producing B cells in peripheral blood
Methodological detailsflow cytometry, RT-qPCR, ELISpot
- Flow cytometry
- RT-qPCR
- ELISpot
Main finding
As reported in the abstract
PFP-producing B cells
- B cells could produce PFP, further enhanced upon anti-BCR and IL-21 stimulation
- Frequencies of PFP-producing B cells decreased in SLE
- Frequencies negatively correlated with clinical characteristics
- Even lower frequencies in SLE patients with vasculitis and pleurisy
Original publication
Decreased perforin-producing B cells correlate with systemic lupus erythematosus. Clin Exp Rheumatol. Published 16 January 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →