Lupus & antiphospholipid syndrome
Patterns of the gut microbiota and metabolome as potential biomarkers associated with influenza vaccine immunogenicity in systemic lupus erythematosus: a cross-sectional observational pilot study
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) who had received influenza vaccination, Ramathibodi Hospital, May 2021–July 202261 fecal samples for metabolomics
- Participants
- 62 patients
- Exposure
- Boosted dose vs standard dose of quadrivalent influenza vaccine; seroconverters vs nonresponders
- Outcome
- Gut microbiota (fecal 16S rDNA) and metabolomic signatures associated with seroconversion (hemagglutination inhibition assay)
Methodological detailsobservational, pilot, single-centre
- Observational
- Pilot
- Single-centre
Main finding
As reported in the abstract
- Genus Bacteroides significantly associated with seroconversion to A(H1N1) and A(H3N2)
- P < 0.05
Observational data: associations, not effects.
Further findings
Age
P = 0.878
Female participants
- Female
- 58/62, 93.6%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Patterns of the gut microbiota and metabolome as potential biomarkers associated with influenza vaccine immunogenicity in systemic lupus erythematosus: a cross-sectional observational pilot study. Arthritis Res Ther. Published 31 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →