Lupus & antiphospholipid syndrome
Clinical phenotypes and disease outcomes of patients with systemic lupus erythematosus meeting indication for primary aldosteronism testing
Authors' conclusion
SLE patients with an indication for PA testing exhibit a phenotype characterised by impaired renal function, increased organ damage and higher prevalence of flare.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) attending a tertiary lupus clinic
- Participants
- 322 patients
- Exposure
- SLE patients with vs without an indication for primary aldosteronism (PA) testing
- Indication for PA testingn = 95
- Outcome
- Associations of indication for PA testing with phenotype and outcomes, within hypertensive patients (multivariable)
Methodological detailssingle-centre (tertiary lupus clinic), multivariable regression
- Single-centre (tertiary lupus clinic)
- Multivariable regression
Main finding
As reported in the abstract
Indication for PA testing vs No indication for PA testingAdjusted odds ratio (95% CI)P value
Reduced baseline renal function
3.29(1.30–9.47)
P = 0.017Higher baseline organ damage
1.94(1.03–3.73)
P = 0.043Higher prevalence of flare throughout the study period
2.86(1.04–8.60)
P = 0.049Observational data: associations, not effects.
Further findings
- Prevalence of indication for PA testing
- 30% · 95
Baseline characteristics, all patients
- Patients with an indication were older, had longer SLE duration, higher BMI, higher blood pressure and more baseline organ damage
Outcomes over clinic attendance, all patients · median 6.8 years
- Patients with an indication had greater accrual of organ damage, higher flare rates and more frequent proteinuria
Original publication
Clinical phenotypes and disease outcomes of patients with systemic lupus erythematosus meeting indication for primary aldosteronism testing. Lupus. Published 31 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →