Lupus & antiphospholipid syndrome
Performance of Risk Score Calculators in the Identification of Coronary Artery Calcification in Patients With Systemic Lupus Erythematosus
Authors' conclusion
The poor performance of conventional and even modified risk scores suggests a continued need for screening approaches, including CAC, to determine CV disease risk in the SLE patient population.
Study context
- Population
- Adult female patients with systemic lupus erythematosus (SLE) and matched controls, excluding those already meeting cardiology guidelines for recommended statin use128 SLE, 138 controls analysed
- Participants
- 128 vs 138
- Comparison
- Atherosclerotic CV Disease (ASCVD) Risk Score vs SLECRISK score for identifying abnormal coronary artery calcification (CAC) in SLE and controls
- SLEn = 128
- Controlsn = 138reference
- Primary endpoint
- Performance (sensitivity, specificity) of cardiovascular (CV) risk tools (ASCVD Risk Score, SLECRISK) in identifying abnormal CAC
Methodological detailsdiagnostic performance, matched controls, logistic regression
- Diagnostic performance
- Matched controls
- Logistic regression
Primary result
As reported in the abstract
| Group | Value | ASCVD Risk Score sensitivity | SLECRISK sensitivity | Mean ASCVD Risk Score |
|---|---|---|---|---|
| SLE | 31.3% | 15% | 30.8% | 2.2% |
| Controls | 12.3% | 17.6% | 1.9% |
Value
SLE31.3%
Controls12.3%
ASCVD Risk Score sensitivity
SLE15%
Controls17.6%
SLECRISK sensitivity
SLE30.8%
Controls— not stated in the abstract
Mean ASCVD Risk Score
SLE2.2%
Controls1.9%
- Specificity of ASCVD Risk Score and SLECRISK score for abnormal CAC
- 95-100%
Further findings
Characteristics of SLE patients with low ASCVD risk and abnormal CAC
- More likely older, lower GFR, longer disease duration, higher insulin resistance, higher LDL and cholesterol
Original publication
Performance of Risk Score Calculators in the Identification of Coronary Artery Calcification in Patients With Systemic Lupus Erythematosus. J Rheumatol. Published 15 November 2025. doi:10.
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