Lupus & antiphospholipid syndrome
Coronary Artery Calcification Progression in Patients With Systemic Lupus Erythematosus
Authors' conclusion
CAC in patients with SLE progressed over time but was not associated with adverse CV events during the first 9 years of follow-up.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) screened for coronary artery calcification (CAC) 9 years before (94.2% women; mean age 41.0 years; mean disease duration 14.8 years)from parent study
- Participants
- 104 patients
- Exposure
- Prevalent CAC cases vs patients without calcification
- CACn = 17
- Without calcificationn = 87reference
- Outcome
- Progression of CAC and associated risk factors
- Follow-up
- 9 years
Methodological detailslongitudinal follow-up at 9 years, multidetector CT
- Longitudinal follow-up at 9 years
- Multidetector CT
Main finding
As reported in the abstract
CAC
- CAC documented
- 17 patients (16.3%)
- Cases from parent study
- 7
- Incident cases
- 10
- Cumulative incidence of CAC
- 9%
- Incidence density
- 1 per 100 person-years
Observational data: associations, not effects.
Further findings
Factors in prevalent CAC vs no calcification
- Similar in traditional cardiovascular (CV) risk factors, disease duration, SLEDAI-2K AUC and Systemic Lupus International Collaborating Clinics (SLICC) score
- CAC more likely postmenopausal and with higher apolipoprotein B (apoB) levels
Previous CAC vs incident cases
- Previous CAC had higher apoB levels, SLEDAI-2K AUC scores and anticardiolipin IgG antibodies
CAC by age group
- More frequent in age groups 30-39 years and 40-44 years
Safety
Clinical CV events in patients with previous CAC
- None developed clinical CV events
- 0
Original publication
Coronary Artery Calcification Progression in Patients With Systemic Lupus Erythematosus. J Rheumatol. Published 1 July 2024. doi:10.
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