Lupus & antiphospholipid syndrome
Performance of SCORE2, QRISK3 and PREVENT equations in systemic lupus erythematosus
Authors' conclusion
Risk scores demonstrated similar and fair discriminative performances but were poorly calibrated except for QRISK3.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients with no prior atherosclerotic cardiovascular disease (ASCVD) who underwent baseline cardiovascular risk assessment including coronary artery calcium (CAC) scoring, French national SLE reference center, 2014–202491% female
- Participants
- 143 patients
- Exposure
- SCORE2 vs QRISK3 vs PREVENT equations for cardiovascular risk prediction in SLE
- Outcome
- Incident ASCVD events: coronary artery disease, stroke and peripheral artery disease
Methodological detailssingle-centre (French national SLE reference center)
- Single-centre (French national SLE reference center)
Main finding
As reported in the abstract
Incident ASCVD events: discrimination (AUC), optimal threshold and calibration (mean observed-to-predicted ratio) · median follow-up 7 years [3-9]
| Group | AUC | Optimal threshold | Mean observed-to-predicted ratio |
|---|---|---|---|
| SCORE2 | 0.81 | 3.9% | 3 |
| QRISK3 | 0.76 | 9.4% | 0.85 |
| PREVENT | 0.80 | 4.3% | 2.8 |
AUC
SCORE20.81
QRISK30.76
PREVENT0.80
Optimal threshold
SCORE23.9%
QRISK39.4%
PREVENT4.3%
Mean observed-to-predicted ratio
SCORE23
QRISK30.85
PREVENT2.8
- Incident ASCVD events (7 coronary artery disease (CAD), 4 strokes, 1 peripheral artery disease (PAD))
- 12 patients (8%)
- AUCs did not significantly differ
- all p > .05
Observational data: associations, not effects.
Secondary outcomes
CAC presence (CAC score >0)
- Similar results were obtained when using CAC as the main outcome
Original publication
Performance of SCORE2, QRISK3 and PREVENT equations in systemic lupus erythematosus. Lupus. Published 1 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →