Lupus & antiphospholipid syndrome
Early risk stratification in lupus nephritis based on established prognostic factors: association with outcomes under triple therapy
Authors' conclusion
These findings suggest that baseline risk stratification identified subgroups in which triple therapy was associated with higher CR rates.
Study context
- Population
- Patients with biopsy-proven class III, IV or V lupus nephritis (LN) treated at the authors' hospital, 2000–2024
- Participants
- 170 patients
- Exposure
- Low- and moderate-risk vs high-risk groups
- Outcome
- Complete renal response (CR)
Methodological detailsmedical record review, single-centre, multivariate logistic regression, Cox proportional hazards models
- Medical record review
- Single-centre
- Multivariate logistic regression
- Cox proportional hazards models
Main finding
As reported in the abstract
CR rates by risk group
Hazard ratio (95% CI)P value
Low-riskvs High-risk
22.8(8.27–81.24)
P < 0.01Moderate-riskvs High-risk
3.7(1.53–9.52)
P = 0.01- Gradient in CR rates across low-, moderate- and high-risk groups
- P < 0.01
Observational data: associations, not effects.
Further findings
Prognostic factors negatively associated with CR (multivariate logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Nephrotic-range proteinuria | 0.25 (0.11–0.55) | P < 0.01 | |
| History of previous LN flare | 0.29 (0.12–0.65) | P < 0.01 | |
| 0.10.31310Odds ratio (log scale) |
CR with triple therapy in the high-risk group (subgroup)
| aHR (95% CI) | P value | ||
|---|---|---|---|
| Triple therapy | 3.13 (1.17–8.73) | P = 0.02 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early risk stratification in lupus nephritis based on established prognostic factors: association with outcomes under triple therapy. Arthritis Res Ther. Published 31 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →