Lupus & antiphospholipid syndrome
Risk of falls, recurrent falls and osteoporotic fractures in SLE patients with comorbid fibromyalgia: a propensity score-matched cohort study using the TriNetX Network
Authors' conclusion
Comorbid FM is significantly and independently associated with increased fall and fracture risk in SLE.
Study context
- Population
- Adult SLE patients, TriNetX US Collaborative Network23,775 matched pairs
- Exposure
- SLE with comorbid fibromyalgia (FM) vs SLE without FM
- Outcome
- Incident falls, recurrent falls, thoracolumbar vertebral fractures and osteoporotic fractures
- Follow-up
- 5 years
Methodological detailspropensity score-matched (1:1), TriNetX US Collaborative Network, 6 month washout period, Kaplan-Meier curves and Cox proportional hazards regression
- Propensity score-matched (1:1)
- TriNetX US Collaborative Network
- 6 month washout period
- Kaplan-Meier curves and Cox proportional hazards regression
Main finding
As reported in the abstract
Falls, recurrent falls, thoracolumbar vertebral fractures and osteoporotic fractures
SLE+FM vs SLE-onlyAdjusted hazard ratio (95% CI)
Incident falls
1.38(1.29–1.48)
Recurrent falls
1.53(1.32–1.76)
Thoracolumbar vertebral fractures
1.18(1.01–1.37)
Osteoporotic fractures
1.14(1.02–1.27)
Observational data: associations, not effects.
Further findings
All outcomes at 3 years and across prespecified subgroups
- Associations directionally consistent at 3 years and across all prespecified subgroups
Original publication
Risk of falls, recurrent falls and osteoporotic fractures in SLE patients with comorbid fibromyalgia: a propensity score-matched cohort study using the TriNetX Network. Lupus Sci Med. Published 27 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →