Lupus & antiphospholipid syndrome
Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States
Authors' conclusion
There is a lack of transitions between employment categories over the disease course, high persistence in the disability benefits, and economically inactive categories and a low probability of reentry after leaving the workforce. Neuropsychiatric and renal damage are key drivers of disability.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), single centre1,155 ever employed
- Participants
- 1,806 patients
- Outcome
- Final employment status (employed, unemployed, disability benefit, retired, economically inactive, death while employed) and transitions between employment states
Methodological detailssingle-centre, multinomial logistic regression, Sankey diagrams
- Single-centre
- Multinomial logistic regression
- Sankey diagrams
Main finding
As reported in the abstract
Permanently transitioned out of employment (of 1,155 ever employed)
398
34.5%
To disability benefits
82
To short-term sick leave
71
Observational data: associations, not effects.
Further findings
Disability benefit category: disease burden
- Highest severe flare rate
- 0.3/year
- GC use >30 mg/day
- 47.8%
- High retention; substantial proportion died during follow-up
Damage domains associated with early retirement
- Malignancy damage, OR
- 2.51
- Endocrine damage, OR
- 2.56
- Musculoskeletal damage, OR
- 1.47
Damage domains associated with disability
- Neuropsychiatric damage, OR
- 1.87
- Renal damage, OR
- 1.89
- Similar patterns to early retirement
Original publication
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