Lupus & antiphospholipid syndrome
One-carbon metabolism upregulated in lupus promotes the differentiation and effector functions of human B and T cells
Authors' conclusion
The SGOC network, particularly MTHFD2, was upregulated in SLE B cells. The 1C metabolism critically promoted the proliferation and effector functions of human B and T cells
Study context
- Population
- B and T cells from SLE patients and healthy controls
- Comparison
- SLE patients vs healthy controls; Serine, glycine and one-carbon (SGOC) inhibitors vs no inhibitor in ex vivo culture
Methodological detailsRT-qPCR, single-cell RNA-seq, ex vivo culture, flow cytometry, ELISA
- RT-qPCR
- Single-cell RNA-seq
- Ex vivo culture
- Flow cytometry
- ELISA
Main finding
As reported in the abstract
- MTHFD2 upregulated in B cells from SLE patients (RT-qPCR)
- Increased expression of PHGDH, PSAT1, SHMT1, SHMT2 and MTHFD2 in B-cell subsets from patients with active SLE (single-cell RNA-seq)
- SGOC inhibition reduced proliferation of human B cells, CD4 T cells and CD8 T cells, and impaired plasma cell differentiation and antibody production
- Inhibiting 1C metabolism blocked IFN-γ production; PHGDH inhibitor reduced IL-17A production by CD4 T cells
Original publication
One-carbon metabolism upregulated in lupus promotes the differentiation and effector functions of human B and T cells. Rheumatology (Oxford). Published 23 July 2026. doi:10.
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