Lupus & antiphospholipid syndrome
Abnormally high expression of D1-like dopamine receptors on lupus CD4+ T cells promotes T follicular helper (Tfh) cell differentiation
Authors' conclusion
Tfh cells in patients with SLE highly express D1-like receptors, which correlate with disease activity. D1-like receptors may promote Tfh cell differentiation through the PI3K/AKT/FOXO1/Klf2 pathway.
Study context
- Population
- Patients with SLE and healthy controls
- Comparison
- Patients with SLE vs healthy controls
- Outcome
- Relationship between DRDs and Tfh cells, and between DRD expression on Tfh cells and the course of SLE
Methodological detailscase-control comparison with healthy controls, in vitro experiments, RNA sequencing (RNA-seq)
- Case-control comparison with healthy controls
- In vitro experiments
- RNA-seq
Main finding
As reported in the abstract
- Plasma dopamine concentration significantly increased in SLE
- Abnormal DRD messenger RNA (mRNA) expression in both peripheral blood mononuclear cells (PBMCs) and CD4+ T cells
- D1-like receptors highly expressed in Tfh cells of patients with SLE and associated with disease activity
- Differentiation of naïve T cells into Tfh cells in vitro accompanied by increased D1-like receptor expression
- D1-like receptors might promote Tfh cell differentiation through the Phosphatidylinositol3-kinase (PI3K)/AKT/FOXO1/Klf2 pathway (RNA-seq and reverse transcription-quantitative PCR (RT-qPCR))
Original publication
Abnormally high expression of D1-like dopamine receptors on lupus CD4+ T cells promotes Tfh cell differentiation. Lupus Sci Med. Published 16 August 2023. doi:10.
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