Lupus & antiphospholipid syndrome
The meaning of non-criteria clinical manifestations in a real-life primary antiphospholipid syndrome cohort
Authors' conclusion
Non-criteria clinical manifestations are common and associated with LA. Among them, neurologic involvement and the presence of livedo were associated with damage accrual.
Study context
- Population
- Patients with primary antiphospholipid syndrome (APS) and/or patients meeting only the serological Sydney criteria with thrombocytopenia and/or haemolytic anaemia78% women
- Participants
- 177 patients
- Outcome
- Prevalence of non-criteria clinical features and their relationship to thrombosis and damage (DIAPS, modified SLICC index)
Methodological detailslogistic regression
- Logistic regression
Main finding
As reported in the abstract
Prevalence of non-criteria clinical manifestations · median follow-up 6.7 years
- Any non-criteria clinical manifestation
- 64%
- Haematologic
- 40.1%
- Cutaneous
- 20.9%
- Neurologic
- 18%
- Cardiac
- 5%
- Renal
- 4.5%
- Thrombosis
- 74%
- Obstetric features
- 29.3%
Observational data: associations, not effects.
Further findings
Factors associated with non-criteria clinical manifestations
| OR (95% CI) | ||
|---|---|---|
| LALogistic regression | 2.3 (1.03–5.1) | |
| Prednisone useLogistic regression | 8.2 (1.7–39.3) | |
| 0.050.21520Odds ratio (log scale) |
Factors associated with DIAPS score ≥1 (damage)
| OR (95% CI) | ||
|---|---|---|
| ThrombosisCI as printed · logistic regression | 53.1 (17.8–15.2) | |
| Prednisone useLogistic regression | 0.27 (0.09–0.83) | |
| Neurological involvementLogistic regression | 6.4 (1.05–39.8) | |
| 0.050.21520Odds ratio (log scale) |
Factors associated with modified SLICC ≥1 (damage)
| OR (95% CI) | ||
|---|---|---|
| ThrombosisLogistic regression | 10.2 (4.43–26.1) | |
| Neurological involvementLogistic regression | 6.4 (1.05–39.8) | |
| Cutaneous featuresLogistic regression | 5.3 (1.4–19) | |
| Livedo reticularisLogistic regression | 5.45 (1.49–19.8) | |
| 0.050.21520Odds ratio (log scale) |
Frequency of each type of non-criteria clinical manifestation
- Haematologic
- 40.1%
- Cutaneous
- 20.9%
- Neurologic
- 18%
- Cardiac
- 5%
- Renal
- 4.5%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The meaning of non-criteria clinical manifestations in a real-life primary antiphospholipid syndrome cohort. Clin Exp Rheumatol. Published 13 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →