Lupus & antiphospholipid syndrome
Patients achieving low lupus disease activity state, systemic lupus erythematosus disease control or remission showed lower rates of organ damage during longitudinal follow-up: analysis of the Hopkins Lupus Cohort
Authors' conclusion
Regardless of definition, achieving and maintaining a low disease activity state was associated with reduced organ damage in patients with SLE.
Study context
- Population
- Adults with systemic lupus erythematosus (SLE) enrolled for ≥1 year in the Hopkins Lupus Cohort, treated with standard therapy in a specialist care centre, 1987–2019
- Participants
- 1,632 adults9841.1 person-years
- Exposure
- Time spent in low disease activity (LDA) states as % of follow-up vs 0%
- Outcome
- Organ damage rate (SLICC/ACR DI) by time spent in LDA states
Methodological detailsreal-world data analysis, single specialist care centre, pooled logistic models
- Real-world data analysis
- Single specialist care centre
- Pooled logistic models
Main finding
As reported in the abstract
Organ damage rate, >0-<25% vs 0% time in LDA state
>0-<25% vs 0%Adjusted relative risk (95% CI)
LLDAS
0.75(0.61–0.91)
Disease control
0.80(0.68–0.93)
Clinical remission
0.73(0.60–0.88)
Complete remission
0.80(0.68–0.93)
- Organ damage events
- 1246
Observational data: associations, not effects.
Original publication
Patients achieving low lupus disease activity state, systemic lupus erythematosus disease control or remission showed lower rates of organ damage during longitudinal follow-up: analysis of the Hopkins Lupus Cohort. Lupus Sci Med. Published 11 December 2024. doi:10.
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