Lupus & antiphospholipid syndrome
Early subclinical macular disease in asymptomatic patients with primary antiphospholipid syndrome: A quantitative multimodal retinal evaluation
Authors' conclusion
PAPS patients present lower vascular density and retinal sensitivity compared to the control group, even in patients without paracentral acute middle maculopathy (PAMM).
Study context
- Population
- Patients with PAPS without ocular complaints followed at a tertiary rheumatology outpatient clinic, and healthy individuals100 eyes
- Participants
- 50 patients
- Exposure
- PAPS without ocular complaints vs healthy individuals
- PAPSn = 25
- Controlsn = 25reference
- Outcome
- Quantitative multimodal retinal evaluation (optical coherence tomography angiography (OCTA) and microperimetry)
Methodological detailscase-control comparison, tertiary rheumatology outpatient clinic
- Case-control comparison
- Tertiary rheumatology outpatient clinic
Main finding
As reported in the abstract
- Significant differences in vascular density, superficial vascular complex (SVC) and deep vascular complex (DVC) (high-speed protocol) and SVC (high-resolution protocol), PAPS vs controls
- Sectoral differences in retinal sensitivity, except inferior sector
- PAPS vs Controls: P = 0.047
- PAPS vs Controls: P = 0.041
- PAPS vs Controls: P < 0.001
Observational data: associations, not effects.
Original publication
Early subclinical macular disease in asymptomatic patients with primary antiphospholipid syndrome: A quantitative multimodal retinal evaluation. Lupus. Published 10 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →