Lupus & antiphospholipid syndrome
Skin and beyond: Demographics, clinical features and systemic involvement of cutaneous lupus erythematosus in Pakistani population
Authors' conclusion
The clinical characteristics of cutaneous lupus is similar to other studies, but the renal involvement is higher with cutaneous involvement in this study, while Serositis is less prevalent. Localized discoid lupus did not show extra cutaneous involvement, but showed significant impact on daily life.
Study context
- Population
- Patients with cutaneous lupus erythematosus (CLE) presenting with cutaneous symptoms, Pakistan
- Participants
- 135 patients
- Outcome
- Clinical features and systemic involvement of CLE
Main finding
As reported in the abstract
- Female
- 73.3%
- Male
- 26.7%
- Mean age (years)
- 28.1
- Duration of CLE (months)
- 8.4
- Rural area
- 56.3%
- Isolated chronic CLE (CCLE)
- 35.5%
- CCLE with overlap acute CLE (ACLE)
- 30.3%
- Isolated ACLE
- 33.3%
- Subacute CLE (patients)
- 2
- Limited discoid rash
- 33.3%
- Generalized discoid rash
- 17.7%
- Malar rash
- 46.6%
- Oral and nasal ulcers
- 51.1 %
- Non-scarring alopecia
- 53.3%
- Scarring alopecia
- 35.5%
- RP
- 34%
- Periungual telangiectasia
- 23.7%
- Vasculitis
- 14.8%
- Joint involvement, 49 patients
- 36.3%
- Renal involvement, 48 patients
- 35.6%
- Haematological involvement, 42 patients
- 31.1%
- Serositis, 23 patients
- 17%
- Neurological involvement, 14 patients
- 10.4%
- ANA positive, 61 patients
- 45.1%
- Anti-dsDNA positive, 42 patients (40 women)
- 31.1%
Observational data: associations, not effects.
Further findings
Impact on daily life (DLQI)
- Mean DLQI
- 11.01 ± 8.2
- No or slight effect on lives (patients)
- 45
- Moderate effect
- 22.9%
- Large effect
- 27.4%
- Very large effect
- 16.3%
Original publication
Skin and beyond: Demographics, clinical features and systemic involvement of cutaneous lupus erythematosus in Pakistani population. Lupus. Published 28 March 2025. doi:10.
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