Lupus & antiphospholipid syndrome
Significant association of functional variants in the promoter sequence of IL18 with disease susceptibility and systemic lupus erythematosus clinical parameters
Authors' conclusion
The study indicates a significant relationship between the rs1946518 and rs187238 variants in IL-18 and a reduced risk of SLE. Furthermore, rs1946518 was found to be associated with certain clinical features related to disease activity and severity.
Study context
- Population
- SLE patients and healthy participants
- Participants
- 251 peripheral blood samples
- Comparison
- SLE patients vs healthy participants: IL18 promoter variants rs1946518 (−607C > A) and rs187238 (−137G > C)
- SLEn = 121
- Healthyn = 130reference
- Outcome
- Association of IL18 variants rs1946518 and rs187238 with risk of SLE
Methodological detailsgenetic association study, high-resolution melting (HRM) genotyping
- Genetic association study
- HRM genotyping
Main finding
As reported in the abstract
Risk of SLE by IL18 genotype/allele
Odds ratio (95% CI)
rs1946518 AAvs rs1946518 CC
0.386(0.174–0.828)
rs1946518 A allelevs rs1946518 C allele
0.548(0.369–0.809)
rs187238 CCvs rs187238 GG
0.240(0.055–0.803)
rs187238 C allelevs rs187238 G allele
0.604(0.390–0.928)
Observational data: associations, not effects.
Further findings
Clinical parameters in SLE patients with rs1946518 protective allele (AA + AC)
- Significantly lower CRP and anti-dsDNA levels, later age of onset, lower incidence of renal involvement and lower creatinine levels
- P < 0.05
Original publication
Significant association of functional variants in the promoter sequence of IL18 with disease susceptibility and systemic lupus erythematosus clinical parameters. Lupus. Published 28 March 2025. doi:10.
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