Lupus & antiphospholipid syndrome
Progenitor cells and circulating endothelial cells are associated with disease activity and damage in systemic lupus erythematosus patients
Authors' conclusion
Our findings reveal that CD34+CD45low/- progenitor cells, CD34+CD45low/-CD133+ progenitor cells, EPC, and CEC are significantly reduced in SLE patients and are associated with disease activity and organ damage.
Study context
- Population
- Patients with Systemic Lupus Erythematosus (SLE) and matched controls
- Participants
- 32 vs 28
- Comparison
- SLE patients vs matched controls
- SLEn = 32
- Controlsn = 28reference
- Outcome
- Peripheral blood levels of CD34+CD45low/- progenitor cells, CD34+CD45low/-CD133+ progenitor cells, Endothelial Progenitor Cells (EPC) and Circulating Endothelial Cells (CEC) (flow cytometry)
Methodological detailsmatched controls, flow cytometry
- Matched controls
- Flow cytometry
Main finding
As reported in the abstract
- SLE vs Controls: P = 0.001
- SLE vs Controls: P = 0.016
- SLE vs Controls: P = 0.018
- SLE vs Controls: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cell levels by organ damage (SDI ≥1 vs no organ damage), SLE patients (subgroup)SDI ≥1 vs No organ damage | P = 0.0073 |
| Cell levels by organ damage (SDI ≥1 vs no organ damage), SLE patients (subgroup)SDI ≥1 vs No organ damage | P = 0.018 |
| Cell levels by organ damage (SDI ≥1 vs no organ damage), SLE patients (subgroup)SDI ≥1 vs No organ damage · EPC significantly higher with SDI ≥1 | P = 0.018 |
| Cell levels by organ damage (SDI ≥1 vs no organ damage), SLE patients (subgroup)SDI ≥1 vs No organ damage · CEC significantly higher with SDI ≥1 | P = 0.020 |
- Cell levels by organ damage (SDI ≥1 vs no organ damage), SLE patients (subgroup): CD34+CD45low/- progenitor cells significantly higher with SDI ≥1
- Cell levels by organ damage (SDI ≥1 vs no organ damage), SLE patients (subgroup): CD34+CD45low/- CD133+ progenitor cells significantly higher with SDI ≥1
Correlation with SLE activity biomarkers
- Cell subpopulations correlated with SLE activity biomarkers; CD34+CD45low/- progenitor cells showed a moderate negative correlation with C3 and C4 levels
Original publication
Progenitor cells and circulating endothelial cells are associated with disease activity and damage in systemic lupus erythematosus patients. Lupus. Published 25 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →