Lupus & antiphospholipid syndrome
Caffeine improves systemic lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
Authors' conclusion
Caffeine intake positively correlated with the percentage of circulating EPCs in SLE patients; moreover, caffeine in vitro treatment was able to improve EPC survival and vitality through the inhibition of apoptosis and the promotion of autophagy via A2AR/SIRT3/AMPK pathway.
Study context
- Population
- SLE patients without traditional cardiovascular risk factors; Endothelial progenitor cells (EPCs) pooled from six healthy donors (HD) co-cultured with SLE sera
- Participants
- 31 SLE patients
- Comparison
- Caffeine vs no caffeine
Methodological detailsex vivo and in vitro
- Ex vivo and in vitro
Main finding
As reported in the abstract
- Positive correlation between caffeine intake and circulating EPCs percentage in SLE patients
- HD EPCs treated with SLE sera and caffeine: improved morphology and number of EPC colony-forming units vs without caffeine
- Caffeine restored autophagy and apoptotic markers in HD EPCs as before SLE sera treatment
- Caffeine significantly reduced A2AR levels, increasing SIRT3 protein levels and subsequently AMPK phosphorylation
Original publication
Caffeine improves systemic lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival. Rheumatology (Oxford). Published 9 October 2024. doi:10.
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