Lupus & antiphospholipid syndrome
5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE
Authors' conclusion
Our findings demonstrate the increased 5hmC distribution in plasma cfDNA in different disease activity in patients with SLE compared with HCs and relating DhMRs involved in SLE-associated pathways.
Study context
- Population
- Patients with SLE and healthy controls
- Comparison
- SLE vs healthy controls
- Outcome
- Distribution of 5hmC in plasma cfDNA and its potential as an SLE diagnosis marker
Methodological detailsgenome-wide 5hmC profiling (5hmC-Seal) of plasma cell-free DNA (cfDNA), in vitro mechanistic exploration
- Genome-wide 5hmC profiling (5hmC-Seal) of plasma cfDNA
- In vitro mechanistic exploration
Main finding
As reported in the abstract
- Genes with hyper-5hmC screened, significantly involved in SLE-related processes
- 151
Original publication
5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE. Lupus Sci Med. Published 4 October 2024. doi:10.
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