Lupus & antiphospholipid syndrome
Assessment of renal response in Tunisian patients with proliferative lupus nephritis under three different induction immunosuppressive agents: A prognostic retrospective study
Main finding · Renal responseResult — go to the resultAdjusted odds ratio 9.846 95% CI 1.087–98.210Authors' conclusion
As an induction treatment for PLN, the High CYP regimen was strongly associated with a higher rate of RR than the MMF regimen. There were no statistically significant differences between the High CYP regimen and the Low CYP regimen in terms of RR.
Study context
- Population
- Kidney biopsy proven proliferative LN patients, Internal Medicine Department, Habib Thameur University Hospital, Tunis, 2000–2023
- Participants
- 78 patients
- Exposure
- High cyclophosphamide (CYP) vs Low CYP vs MMF induction regimens
- High CYPn = 17
- Low CYPn = 40
- MMFn = 21reference
- Outcome
- Incidence of renal response (complete and partial remission)
- Follow-up
- One year post-diagnosis
Methodological detailsprognostic, single-centre
- Prognostic
- Single-centre
Main finding
Renal response
Adjusted odds ratio
9.846
95% CI 1.087–98.210
P = 0.042
By group
High CYPvs MMF
aOR 9.846 (95% CI 1.087–98.210); P = 0.042
As reported in the abstract
Observational data: associations, not effects.
Further findings
Events
| Outcome | Low CYP | MMF |
|---|---|---|
| ESKD | 3 | — not stated in the abstract |
| Death | 4 | 1 |
— not stated in the abstract
- Death — Total deaths
- 5
End-stage kidney disease (ESKD)
- 3 cases of ESKD, all in the Low CYP group
Safety
Events
| Outcome | High CYP | Low CYP | MMF |
|---|---|---|---|
| Severe AEs (all severe infections) | 5 | 12 | 3 |
- Severe adverse events (AEs) (all severe infections): 20 cases of severe AEs
Original publication
Assessment of renal response in Tunisian patients with proliferative lupus nephritis under three different induction immunosuppressive agents: A prognostic retrospective study. Lupus. Published 3 October 2024. doi:10.
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