Lupus & antiphospholipid syndrome
Dancing with disorder: chorea – an unusual and neglected manifestation of antiphospholipid syndrome
Authors' conclusion
Chorea is a significant but under-recognised manifestation of APS, predominantly affecting young women and often presenting as the initial symptom.
Study context
- Population
- Patients with incident aPL-associated chorea: Peking Union Medical College Hospital (PUMCH) admissions 2014–2024 and cases from public databases since 198313 PUMCH, 167 literature
- Participants
- 180 patients
- Outcome
- Clinical, laboratory and imaging features of aPL-associated chorea
Methodological detailsmixed-methods, single-centre cohort (PUMCH, 2014–2024) combined with published cases since 1983
- Mixed-methods
- Single-centre cohort (PUMCH, 2014–2024) combined with published cases since 1983
Main finding
As reported in the abstract
- Female
- 81.7%
- Age at chorea onset, mean (SD)
- 22.8 years (SD=16.0)
- Chorea as initial symptom
- 87.9%
- Single episode
- 67%
- Bilateral limbs
- 58.8%
- Both upper and lower limbs
- 87.2%
- Met 2023 American College of Rheumatology (ACR)/EULAR antiphospholipid syndrome (APS) classification criteria
- 43.3%
- Thrombocytopenia
- 30.0%
- Arterial thrombosis
- 29.1%
- LA positive
- 84.2%
- aCL IgG positive
- 70.8%
- Anti-β2 glycoprotein I IgG positive
- 52.9%
- Triple-positive (among those with all three tests)
- 57.6%
- ANA positive
- 63.6%
- MRI basal ganglia lesions
- 14.8%
- Positron emission tomography (PET) contralateral striatal hypermetabolism
- all PET scans
- Chorea completely or partially improved
- 95.5%
Observational data: associations, not effects.
Original publication
Dancing with disorder: chorea – an unusual and neglected manifestation of antiphospholipid syndrome. Lupus Sci Med. Published 1 October 2024. doi:10.
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