Lupus & antiphospholipid syndrome
Serum S100A8 as a potential biomarker for diagnosis of antiphospholipid syndrome and risk stratification among aPL carriers
Authors' conclusion
S100A8 may serve as a complementary biomarker for the diagnosis and risk stratification of APS, especially in female aPL carriers at risk of obstetric morbidity.
Study context
- Population
- Healthy controls, aPL carriers without manifestation and patients with antiphospholipid syndrome (APS)
- Participants
- 120 / 57 / 114
- Comparison
- Serum S100A8 in APS and aPL carriers vs healthy controls
- Healthy controls (HCs)n = 120reference
- aPL carriersn = 57
- APSn = 114
- Outcome
- Diagnostic performance of serum S100A8 (ELISA) for APS
Methodological detailscase-control, ROC curve analysis, multivariate logistic regression
- Case-control
- ROC curve analysis
- Multivariate logistic regression
Performance
As reported in the abstract
| Test or model | Value | AUC |
|---|---|---|
| aPL carriers | median 44.3 (IQR 35.6–75.4) ng/mL | |
| APS | 52.8 (IQR 37.2–79.2) ng/mL | 0.854 (95% CI 0.803 to 0.907, p<0.001) |
| HCs | 25 (IQR 21.6–31.1) ng/mL |
Value
aPL carriersmedian 44.3 (IQR 35.6–75.4) ng/mL
APS52.8 (IQR 37.2–79.2) ng/mL
HCs25 (IQR 21.6–31.1) ng/mL
AUC
aPL carriers— not stated in the abstract
APS0.854 (95% CI 0.803 to 0.907, p<0.001)
HCs— not stated in the abstract
- aPL carriers vs HCs: P < 0.001 — significantly higher
- APS vs HCs: P < 0.001 — significantly higher
Further findings
Obstetric APS risk among aPL carriers
| OR (95% CI) | P value | ||
|---|---|---|---|
| S100A8 positivityIndependently associated with increased risk · multivariate logistic regression | 3.335 (1.010–11.012) | P = 0.048 | |
| 0.050.21520Odds ratio (log scale) |
Diagnostic accuracy of S100A8 for thrombotic APS
- AUC
- 0.819 (95% CI 0.747 to 0.891, p<0.001)
Diagnostic accuracy of S100A8 for obstetric APS
- AUC
- 0.874 (95% CI 0.821 to 0.926, p<0.001)
Original publication
Serum S100A8 as a potential biomarker for diagnosis of antiphospholipid syndrome and risk stratification among aPL carriers. Lupus Sci Med. Published 9 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →