Lupus & antiphospholipid syndrome
Antiphospholipid antibody-related clinical manifestations during childhood versus adulthood: descriptive results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (antiphospholipid syndrome (APS) ACTION) clinical database and repository
Authors' conclusion
Our analysis of an international registry for persistently aPL-positive patients demonstrates that patients with paediatric-onset aPL-related manifestations more commonly present with non-vascular events.
Study context
- Population
- Persistently aPL-positive adult patients in an international registry (APS ACTION)
- Participants
- 787 patients
- Exposure
- Paediatric-onset vs adult-onset aPL-related manifestations
- Paediatric-onsetn = 45
- Adult-onsetn = 742reference
- Outcome
- Frequency of vascular and non-vascular events at first aPL-related manifestation
Methodological detailsinternational registry, descriptive
- International registry
- Descriptive
Main finding
As reported in the abstract
Presentation with a non-vascular event
P = 0.0001
Observational data: associations, not effects.
Further findings
Type of clinical events (all patients)
- Only vascular events
- 447 (57%)
- Only non-vascular events
- 108 (14%)
- Both
- 232 (29%)
Non-vascular presentation by narrower age groups
- Percentage presenting with a non-vascular event mostly decreased with each increasing age group
Timeline from first clinical event to first positive aPL test
- Within same calendar year
- 317 (40%)
- Within 1 to 3 calendar years
- 207 (26%)
- More than 3 calendar years
- 263 (33%)
Original publication
Antiphospholipid antibody-related clinical manifestations during childhood versus adulthood: descriptive results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) clinical database and repository. Clin Exp Rheumatol. Published 23 March 2025. doi:10.
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