Lupus & antiphospholipid syndrome
Association between extracellular vesicles (EVs) and thrombosis in antiphospholipid syndrome
Authors' conclusion
EVs expressing antigens related to platelet and endothelial cell activation and adhesion, as well as platelet-leukocyte interaction, were associated with thrombosis related to APS.
Study context
- Population
- Patients with thrombotic APS and healthy controls
- Participants
- 69 vs 46
- Comparison
- Thrombotic APS vs healthy controls
- Thrombotic APS (t-APS)n = 69
- Healthy controls (HC)n = 46reference
- Outcome
- Circulating EV levels (CD41, CD162, CD31, CD142, CD62) and association with APS-related thrombosis and inflammatory markers
Methodological detailsflow cytometry
- Flow cytometry
Main finding
As reported in the abstract
Circulating EV levels, t-APS vs HC
- CD162+EV, CD31+EV and CD41+EV levels higher in t-APS than controls
Observational data: associations, not effects.
Further findings
CD41+EV levels and thrombosis type in t-APS
- CD41+EV associated with venous thrombosis
- P = 0.04
- CD41+EV and multiple thrombosis
- P = 0.07
Correlation of EV levels with IL-1β
- CD162+EV, CD31+EV, CD142+EV and CD62P+EV positively correlated with IL-1β
Original publication
Association between extracellular vesicles (EVs) and thrombosis in antiphospholipid syndrome. Lupus. Published 23 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →