Lupus & antiphospholipid syndrome
Does the standard proteinuria cut-off for renal biopsy in lupus nephritis as per the current guidelines hold good for Asian population? A single-centre study from South India
Authors' conclusion
Significant renal lesions were seen in around half of the patients with low-grade proteinuria underscoring the importance of performing a renal biopsy in this set of patients.
Study context
- Population
- Consecutive patients with LN and low-grade proteinuria (200 mg to 500 mg/24 h) undergoing renal biopsy, single centre, South India167 (91.2%) female
- Participants
- 183 patients
- Outcome
- Nature of renal lesions (significant: Class III/IV/V; non-significant: Class I and II) in patients with low-grade proteinuria, and predictors of clinically significant LN
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Renal biopsy lesions
Proliferative LN
85 patients
46.5%
Membranous nephropathy
17 patients
9.3%
Crescents
10
5.46%
Fibrinoid necrosis
24
13.11 %
Observational data: associations, not effects.
Further findings
Isolated proteinuria without other sediments
- Isolated proteinuria
- 95 patients (51.9%)
- Of these, proliferative LN
- 29
Predictors of significant renal lesions
- Elevated Anti-double stranded DNA (anti-dsDNA), low C3, low C4 and urinary sediments significantly associated with significant renal lesions
Original publication
Does the standard proteinuria cut-off for renal biopsy in lupus nephritis as per the current guidelines hold good for Asian population? A single-centre study from South India. Lupus. Published 3 October 2024. doi:10.
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