Lupus & antiphospholipid syndrome
A novel long noncoding RNA ENST00000597482 serves as a potential biomarker for disease activity and diagnosis of systemic lupus erythematosus
Authors' conclusion
LncRNA ENST00000597482 expression was lower in PBMCs from SLE patients than HCs and was negatively correlated with the SLEDAI-2K score and autoantibody titres.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy controls (HCs); Peripheral blood mononuclear cells (PBMCs)72 SLE patients for correlation
- Comparison
- SLE patients vs healthy controls
- Outcome
- lncRNA expression profiles in PBMCs
Methodological detailslncRNA sequencing, real-time quantitative polymerase chain reaction (RT-qPCR) validation, ROC curve analysis
- lncRNA sequencing
- RT-qPCR validation
- ROC curve analysis
Main finding
As reported in the abstract
LncRNA expression profiles in PBMCs, SLE vs HCs
Differentially expressed long noncoding RNAs (lncRNAs) in SLE PBMCs vs HCs
218
Upregulated lncRNAs
121
Downregulated lncRNAs
97
Only lncRNA ENST00000597482 of the candidate genes selected was consistent with sequencing; lower in SLE PBMCs than in HCs
10 candidate genes
Further findings
Correlation of ENST00000597482 with disease activity and autoantibodies
- Negatively correlated with SLEDAI-2K score and ANA and anti-dsDNA titres
Organ involvement
- SLE patients with lower ENST00000597482 expression prone to organ involvement
Diagnostic value (ROC)
- Potential diagnostic value in differentiating SLE from HCs
Original publication
A novel long noncoding RNA ENST00000597482 serves as a potential biomarker for disease activity and diagnosis of systemic lupus erythematosus. Lupus. Published 22 July 2024. doi:10.
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