Lupus & antiphospholipid syndrome
Characteristics and prognosis of elderly-onset antiphospholipid syndrome: An observational cohort study
Authors' conclusion
Elderly-onset APS patients have unique disease characteristics with higher 10-years cumulative all-cause mortality and APS-related mortality.
Study context
- Population
- Thrombotic antiphospholipid syndrome (APS) patients followed up between 2009 and 2022
- Participants
- 161 APS patients
- Exposure
- Elderly-onset APS (onset ≥60 years) vs non-elderly-onset APS (onset <60 years) and matched elderly non-APS patients with thrombosis
- Elderly-onset APSn = 45
- Outcome
- 10-year cumulative all-cause mortality
- Follow-up
- 10 years
Methodological detailsmatched elderly non-APS comparators
- Matched elderly non-APS comparators
Main finding
As reported in the abstract
- Elderly-onset APS vs Non-elderly-onset APS: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Elderly-onset APS | Non-elderly-onset APS | P value |
|---|---|---|---|
| Stroke at disease onsetElderly-onset APS vs Non-elderly-onset APS | 35.6% | 18.1% | P = 0.018 |
| LA positive rateElderly-onset APS vs Non-elderly-onset APS | 51.1% | 71.6% | P = 0.014 |
| LA ratioElderly-onset APS vs Non-elderly-onset APS | 1.24 (range as printed 1.01–1.38) | 1.37 (range as printed 1.16–1.77) | P = 0.004 |
- 10-year APS-related mortality · 10 years · Elderly-onset APS vs Non-elderly-onset APS · higher in elderly-onset APS
- P = 0.002
- 10-year APS-related mortality · 10 years · Elderly-onset APS vs Elderly non-APS · higher in elderly-onset APS
- P = 0.040
Cardiovascular risk factors
- Elderly-onset APS associated with a higher number of cardiovascular risk factors vs non-elderly-onset
Original publication
Characteristics and prognosis of elderly-onset antiphospholipid syndrome: An observational cohort study. Lupus. Published 21 July 2024. doi:10.
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