Lupus & antiphospholipid syndrome
Downregulation of circETS1 disrupts Th17/Treg homeostasis by inhibiting FOXP3 transcription: A new potential biomarker in systemic lupus erythematosus
Authors' conclusion
The imbalance in Th17/Treg cells in SLE may be attributed, in part, to the circETS1/miR-1205/FOXP3 pathway.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy controls; Peripheral blood mononuclear cells (PBMCs) and CD4+ T cells
- Participants
- 28 vs 20
- Comparison
- Patients with SLE vs healthy controls
- SLEn = 28
- Healthy controlsn = 20reference
- Outcome
- circETS1 and FOXP3 expression in PBMCs and CD4+ T cells
Methodological detailscase-control, dual-luciferase reporter, gain-/loss-of-function and rescue assays, ROC analysis
- Case-control
- Dual-luciferase reporter, gain-/loss-of-function and rescue assays
- ROC analysis
Main finding
As reported in the abstract
- circETS1 and FOXP3 expression downregulated in PBMCs and CD4+ T cells of SLE vs healthy controls
- circETS1 binds miR-1205 directly, acting as a sponge to upregulate FOXP3 transcription, maintaining Th17/Treg balance
Further findings
- Diagnostic value of PBMC circETS1 for SLE (ROC)
- 0.873 (95% CI 0.771-0.976; p < .001) · AUC · sensitivity 80.00% · specificity 89.29%
Correlation of PBMC circETS1 with disease activity (SLEDAI) in SLE
- Negative correlation, r
- −0.7712 (95% CI −0.8910 to −0.5509; p < .001)
Original publication
Downregulation of circETS1 disrupts Th17/Treg homeostasis by inhibiting FOXP3 transcription: A new potential biomarker in systemic lupus erythematosus. Lupus. Published 18 October 2023. doi:10.
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