Lupus & antiphospholipid syndrome
Novel endothelial progenitor cells populations as biomarkers of damage and remission in systemic lupus erythematosus
Authors' conclusion
Our novel approach identified clusters of EPCs in patients with SLE that are associated with remission and damage.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy controls; Peripheral blood mononuclear cells (PBMCs) analysed
- Comparison
- SLE vs healthy controls
- Outcome
- EPC-specific subpopulations identified by flow cytometry
Methodological detailsflow cytometry, quantitative PCR (qPCR), tSNE-CUDA dimensionality reduction
- Flow cytometry
- qPCR
- tSNE-CUDA dimensionality reduction
Main finding
As reported in the abstract
PBMC clusters (tSNE-CUDA)
Eight different clusters identified in PBMCs from healthy controls (HC) and SLE
8
Three clusters with EPC-like phenotype, expression elevated in SLE
3
Four SLE-associated subclusters, only present in SLE patients in remission, significantly associated with the 2021 Definition of Remission in SLE
4
Original publication
Novel endothelial progenitor cells populations as biomarkers of damage and remission in systemic lupus erythematosus. Arthritis Res Ther. Published 28 September 2024. doi:10.
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