Lupus & antiphospholipid syndrome
Evaluation of survivin expression and regulating miRNAs of survivin expression in peripheral blood mononuclear cells in systemic lupus erythematous patients
Main finding · Expression of survivin, its variants and survivin-regulating miRNAs in PBMCs (qRT-PCR)Result — go to the resultFold change 0.63Authors' conclusion
Although survivin-TS and its two variants (survivin-2B, and survivin-ΔEx3) were not differently expressed in SLE patients, survivin-WT had altered expression.
Study context
- Population
- Inactive SLE patients and healthy controls; PBMCs analysed by quantitative real-time PCR
- Participants
- 50 vs 50
- Comparison
- Inactive SLE vs healthy controls
- SLEn = 50
- Healthy controlsn = 50reference
- Outcome
- Expression levels of survivin (total and variants) and survivin-regulating miRNAs in PBMCs
Main finding
As reported in the abstract
Expression of survivin, its variants and survivin-regulating miRNAs in PBMCs (qRT-PCR)
Fold change
0.63
p++ = 0.002
- miR-34a-5p expression significantly increased (fold change; p++ = 0.027)
- 1.5
- miR-218-5p expression significantly increased (fold change; p++ = 0.020)
- 1.5
- miR-150-5p expression significantly decreased (fold change; p++ = 0.003)
- 0.56
Observational data: associations, not effects.
Original publication
Evaluation of survivin expression and regulating miRNAs of survivin expression in peripheral blood mononuclear cells in systemic lupus erythematous patients. Lupus. Published 20 August 2024. doi:10.
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