Lupus & antiphospholipid syndrome
rs6897932 (C>T) and rs987106 (A>T) variants in the IL7RA gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus
Authors' conclusion
The findings suggest that the T allele of rs6897932 in the IL7RA may provide a protective effect against the development of SLE. Although no significant association was found between rs987106 and SLE risk, it may still contribute to the disease's etiopathology, particularly concerning renal complications.
Study context
- Population
- Iranian individuals with systemic lupus erythematosus (SLE) and healthy Iranian controls
- Participants
- 105 vs 105
- Comparison
- SLE patients vs healthy controls
- SLEn = 105
- Healthy controlsn = 105reference
- Outcome
- Association of IL7RA single-nucleotide polymorphisms (SNPs) rs6897932 (C>T) and rs987106 (A>T) with SLE risk
Methodological detailshigh-resolution melting genotyping
- High-resolution melting genotyping
Main finding
As reported in the abstract
SLE risk by IL7RA SNPs
- rs6897932, dominant model: CT+TT genotypes associated with decreased SLE risk
- P = .009
- rs6897932 T allele less frequent in patients than healthy controls
- P = .005
- rs987106: no significant association with SLE risk in any inheritance model
- P > .05
- rs987106 T allele frequency: no significant difference between groups
- P = .434
Observational data: associations, not effects.
Further findings
C-reactive protein (CRP) levels, CC vs CT or TT genotype of rs6897932 (patients)
- CRP the only laboratory parameter differing significantly between CC and CT/TT
- P = 0.007
rs987106 TT genotype and clinical features
- TT genotype correlated with higher serum anti-dsDNA and creatinine and more patients with renal involvement
Original publication
rs6897932 (C>T) and rs987106 (A>T) variants in the IL7RA gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus. Lupus. Published 21 February 2026. doi:10.
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