Lupus & antiphospholipid syndrome
Measurements of urinary biomarkers at 2 years following a lupus nephritis flare are associated with subsequent renal outcomes
Authors' conclusion
UBs measured 24±3 months after an LN flare were associated with subsequent flares and a clinically meaningful decline in kidney function.
Study context
- Population
- Patients with an lupus nephritis (LN) flare, preflare estimated glomerular filtration rate (eGFR) ≥60 mL/min and stored urine 24±3 months after the flaremedian follow-up 129 months
- Participants
- 69 patients
- Exposure
- Urinary biomarker levels measured 24±3 months after an LN flare and subsequent renal outcomes
- Outcome
- (1) Time to a subsequent LN flare and (2) time to 30% sustained decline in eGFR
Main finding
As reported in the abstract
Prediction of subsequent LN flare (elevated UB levels)
MCP-1, HR
1.40
1.11–1.76p=0.004
CD163, HR
1.14
1.00–1.38p=0.01
Observational data: associations, not effects.
Further findings
Prediction of 30% decline in eGFR
- CD163, HR
- 1.16 (1.02-1.32), p=0.02
- MCP-1, HR
- 1.33 (1.01-1.74), p=0.04
- Adiponectin, HR
- 2.67 (1.68-2.46), p<0.001
- PF4, HR
- 1.14 (1.04-1.25), p=0.002
Renal responders at 24 months (subcohort) · 24 months after LN flare
- Achieved primary efficacy renal response
- 50
- Subsequent LN flare
- 27 (54%)
- Median time to flare (IQR), years
- 3.5 (1.67-6.87)
- 30% decline in eGFR
- 10 (20%)
- Median time to 30% eGFR decline, years
- 4.38 (3.73-5.33)
- Significantly lower UB levels in this subcohort
Original publication
Measurements of urinary biomarkers at 2 years following a lupus nephritis flare are associated with subsequent renal outcomes. Lupus Sci Med. Published 19 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →