Lupus & antiphospholipid syndrome
Interferon-α as a biomarker to predict renal outcomes in lupus nephritis
Authors' conclusion
Elevated serum IFN-α levels measured at the time of an LN flare are associated with poor renal outcomes, including the development of ≥2 LN flares, and a clinically meaningful decline in kidney function.
Study context
- Population
- Patients with an lupus nephritis (LN) flare and preflare estimated glomerular filtration rate (eGFR) ≥60 mL/minactive LN
- Participants
- 92 patients
- Exposure
- Higher vs lower baseline serum interferon (IFN)-α at LN flare
- Outcome
- Renal outcomes: time to first and second LN flares; time to sustained eGFR decline by 30% and 50% and progression to end-stage renal disease (ESRD) (<15 mL/min); time to an adverse renal event (≥2 renal flares and/or ≥30% sustained eGFR decline)
Methodological detailsSerum IFN-α measured by Simoa
- Serum IFN-α measured by Simoa
Main finding
As reported in the abstract
Renal outcomes by higher baseline serum IFN-α
Higher baseline IFN-αHazard ratio (CI)P value
≥2 subsequent LN flares
1.31(1.08–1.59)
P = 0.006Sustained 30% decline in eGFR
1.27(1.14–1.40)
P < 0.00150% decline in eGFR
1.27(1.12–1.33)
P < 0.001Progression to ESRD
1.29(1.14–1.47)
P < 0.001Observational data: associations, not effects.
Further findings
ROC-derived IFN-α cut-off for predicting an adverse renal event
- IFN-α cut-off
- 0.6 pg/ml
Original publication
Interferon-α as a biomarker to predict renal outcomes in lupus nephritis. Lupus Sci Med. Published 28 November 2024. doi:10.
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