Lupus & antiphospholipid syndrome
Risk of chronic kidney disease in newly diagnosed SLE with preserved renal function: a national study
Main finding · Incident CKDResult — go to the resultHazard ratio 1.96 95% CI 1.50–2.54Authors' conclusion
Patients with SLE and preserved kidney function at diagnosis, without LN, are at increased risk of adverse renal outcomes, cardiovascular events and mortality
Study context
- Population
- Newly diagnosed patients with SLE between 2015 and 2023 with estimated glomerular filtration rate (eGFR) > 60 ml/min/1.73 m² and no LN, national databasemedian follow-up 5.77 years
- Participants
- 1,145 vs 91,681
- Exposure
- Newly diagnosed SLE with preserved kidney function and no LN vs matched non-SLE controls
- SLEn = 1,145
- Controlsn = 91,681reference
- Outcome
- Incident CKD, defined as eGFR ≤ 60 ml/min/1.73 m² after diagnosis
Methodological detailsnational database, matched by age, sex and ethnicity
- National database
- Matched by age, sex and ethnicity
Main finding
Incident CKD
Hazard ratio
1.96
95% CI 1.50–2.54
By group
SLEvs Controls
HR 1.96 (95% CI 1.50–2.54)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| ESKD | 3.13 (1.38–7.08) | |
| MACE | 1.63 (1.31–2.04) | |
| All-cause mortality | 4.52 (3.71–5.50) | |
| 0.10.31310Hazard ratio (log scale) |
Baseline eGFR
Mean eGFR trajectories
- Similar between the groups
Risk factors for CKD and end-stage kidney disease (ESKD) (strongest)
- Diabetes HR
- 1.51 (95% CI 1.39-1.64)
- Hypertension HR
- 2.72 (95% CI 2.42-3.07)
Original publication
Risk of chronic kidney disease in newly diagnosed SLE with preserved renal function: a national study. Rheumatology (Oxford). Published 16 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →