Lupus & antiphospholipid syndrome
Prevalence, Risk Factors, and Outcomes of Chronic Kidney Disease in Patients With Systemic Lupus Erythematosus With and Without Lupus Nephritis
Authors' conclusion
CKD is highly prevalent in SLE, including in patients without prior LN. CKD is associated with increased morbidity and mortality.
Study context
- Population
- Adult patients with systemic lupus erythematosus (SLE), with and without lupus nephritis (LN), single centre, 2014–2023mean follow-up 18.3 (SD 14.7) years
- Participants
- 175 patients
- Exposure
- SLE with vs without chronic kidney disease (CKD); LN vs no LN
- CKDn = 89
- Outcome
- CKD prevalence
Methodological detailssingle-centre, medical records review
- Single-centre
- Medical records review
Main finding
As reported in the abstract
CKD diagnosed (89/163)
54.6%
Reduced estimated glomerular filtration rate (eGFR) only
15.7%
Albuminuria only
52.8%
Both
31.5%
Observational data: associations, not effects.
Further findings
Mortality · predictor in univariate and multivariable analyses
P < 0.001
| Outcome | HR |
|---|---|
| CKD risk with LN | 5.4 |
- CKD risk with LN — CKD patients with no history of LN
- 46.1%
- CKD risk with LN: LN strongest predictor; age and lower eGFR at diagnosis other predictors
Kidney replacement therapy
- Required kidney replacement therapy
- 12
Morbidity
- CKD associated with increased CV morbidity and hospitalization for SLE exacerbations and infections
Original publication
Prevalence, Risk Factors, and Outcomes of Chronic Kidney Disease in Patients With Systemic Lupus Erythematosus With and Without Lupus Nephritis. J Rheumatol. Published 1 July 2025. doi:10.
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