Lupus & antiphospholipid syndrome
Metabolic profiles of cutaneous lupus have abnormalities in the nicotinamide adenine dinucleotide pathway
Authors' conclusion
Metabolites associated with the NAD+ pathway may be dysregulated in the skin of patients with CLE.
Study context
- Population
- Patients with cutaneous lupus erythematosus (CLE) and normal controls, outpatient dermatology clinics, University of Texas Southwestern and Parkland Health, Dallas, Texas, January 2019 to October 202017 serum and 11 skin samples
- Exposure
- CLE vs normal controls
- Outcome
- Metabolomic profiles (metabolite levels) in skin and sera, CLE vs controls, by LC-MS
Methodological detailspilot study, liquid chromatography-mass spectrometry (LC-MS) metabolomics, significance adjusted for multiple hypothesis testing
- Pilot study
- LC-MS metabolomics
- Significance adjusted for multiple hypothesis testing
Main finding
As reported in the abstract
Metabolites of differential abundance, CLE skin vs control skin
- Citrulline, increased
- log2FC 1.15; P = 0.02
- Uracil, increased
- log2FC 1.79; P = 0.04
- Cyclic ADP ribose (cADPr), downregulated
- log2FC 0.83; P = 0.04
- Nicotinamide mononucleotide (NMN), downregulated
- log2FC 0.75; P = 0.016
- NAD+, downregulated
- log2FC 0.86; P = 0.016
- Metabolites of differential abundance in CLE skin
- 11
Observational data: associations, not effects.
Further findings
| Outcome | log2FC | P value |
|---|---|---|
| Metabolites of differential abundance, CLE sera vs control seraCLE vs Control · arabinose, increased | 1.17 | P = 0.02 |
| Metabolites of differential abundance, CLE sera vs control seraCLE vs Control · cystine, increased | 1.04 | P = 0.03 |
- Metabolites of differential abundance, CLE sera vs control sera — Metabolites of differential abundance in CLE sera
- 2
- Metabolites of differential abundance, CLE sera vs control sera: 17 serum samples (9 CLE, 8 control)
Original publication
Metabolic profiles of cutaneous lupus have abnormalities in the nicotinamide adenine dinucleotide pathway. Lupus Sci Med. Published 25 January 2025. doi:10.
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