Lupus & antiphospholipid syndrome
Epidemiology of Isolated Cutaneous Lupus Erythematosus in the Multiethnic Population of Reunion Island: A Retrospective Multicenter Study
Authors' conclusion
The prevalence and incidence of CLE in the multiethnic population of Reunion Island seem higher than in light-skinned populations.
Study context
- Population
- Patients with isolated cutaneous lupus erythematosus (CLE) (not fulfilling systemic lupus erythematosus (SLE) criteria), all public hospitals and private dermatology practices in Reunion Island, France; multiethnic population including dark skin218 incident cases
- Participants
- 268 patients
- Outcome
- Prevalence and incidence of isolated CLE
- Follow-up
- Incident cases 2008–2021; prevalence on January 1, 2022
Methodological detailsmulticentre, capture-recapture analysis
- Multicentre
- Capture-recapture analysis
Main finding
As reported in the abstract
Standardized prevalence (per 100,000 persons)
43
Average annual standardized incidence (per 100,000 person-years (PY))
3.1
Capture-recapture estimated prevalence
99
per 100,000 persons; 95% CI 77.10–136.45
Capture-recapture estimated annual incidence
5.7
per 100,000 PY; 95% CI 4.40–7.95
Observational data: associations, not effects.
Further findings
Clinical characteristics
- Mean age at diagnosis (years)
- 41.7
- Female to male ratio
- 4:1
- Patients with dark skin had a higher rate of discoid CLE and were more likely to receive immunosuppressants
- Generalized discoid CLE, panniculitis and overlapping CLE subtypes appeared as predictive markers of progression toward SLE
Original publication
Epidemiology of Isolated Cutaneous Lupus Erythematosus in the Multiethnic Population of Reunion Island: A Retrospective Multicenter Study. J Rheumatol. Published 1 December 2024. doi:10.
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