Lupus & antiphospholipid syndrome
Peripartum maternal outcomes in individuals with systemic lupus erythematosus in a real-world electronic health record cohort
Main finding · Peripartum infection (mixed effects model, adjusted for race)Result — go to the resultOdds ratio 6.18 95 % CI 2.73–13.98Authors' conclusion
Individuals with SLE have increased rates of blood transfusions, longer hospital stays, and more frequent infections compared to control individuals in the peripartum period. We observed a postpartum flare rate of 32 %, and antimalarial use was associated with lower flare rate.
Study context
- Population
- Deliveries in a de-identified electronic health record (EHR) cohort of individuals with and without systemic lupus erythematosus (SLE)
- Exposure
- SLE deliveries vs control deliveries without autoimmune disease
- SLEn = 185 deliveries to 142 individuals
- Controlsn = 468 deliveries to 241 control individualsreference
- Outcome
- Peripartum maternal outcomes: maternal infections, blood transfusions, hospital LOS and SLE flares
Methodological detailsde-identified EHR cohort, mixed effects models, chart review
- De-identified EHR cohort
- Mixed effects models
- Chart review
Main finding
As reported in the abstract
Peripartum infection (mixed effects model, adjusted for race) · up to 6 weeks postpartum
Odds ratio
6.18
95 % CI 2.73–13.98
P < 0.01
SLEvs Controls
OR 6.18 (95 % CI 2.73–13.98); P < 0.01
- Cesarean section associated with peripartum infection, OR
- 5.00 (95 % CI 2.16 - 11.57, p < 0.01)
- Age at delivery associated with peripartum infection, OR
- 0.92 (95 % CI 0.86 - 0.99, p = 0.03)
Observational data: associations, not effects.
Further findings
Hospital LOS
P < 0.001
| Outcome | OR (95 % CI) | P value | |
|---|---|---|---|
| Blood transfusion (mixed effects model, adjusted for Cesarean section and age at delivery)Adjusted for Cesarean section and age at delivery | 9.05 (3.24–25.32) | P < 0.01 | |
| 0.050.21520Odds ratio (log scale) |
- Blood transfusion (mixed effects model, adjusted for Cesarean section and age at delivery) — Black race associated with transfusion, OR
- 6.64 (95 % CI 1.47 - 30.02, p = 0.01)
- Postpartum SLE flare rate (SELENA Flare Index) · up to 6 months postpartum
- 32 %
Flare rate by postpartum antimalarial use (SLE subgroup)
- Antimalarial use in the postpartum period associated with lower flare rate (43 % vs. 63 %, p = 0.04)
Original publication
Peripartum maternal outcomes in individuals with systemic lupus erythematosus in a real-world electronic health record cohort. Semin Arthritis Rheum. Published 30 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →