Lupus & antiphospholipid syndrome
Development and validation of a risk scoring system to identify patients with lupus nephritis in electronic health record data
Authors' conclusion
This study quantified the underutilisation of LN diagnosis codes in EHRs and introduced two adaptable scoring systems to enhance LN identification.
Study context
- Population
- Adults with ICD9/10 codes for SLE in electronic health records (EHRs) of two large health systems (UCSF Medical Center; Zuckerberg San Francisco General Hospital); mean age 50 years, 87% female4,152 UCSF + 370 external
- Comparison
- Lupus nephritis (LN) ICD9/10 codes, LN-Code and LN-No Code scoring systems for identifying LN in EHR data
- Outcome
- Identification of LN (chart review by rheumatologists; strict and inclusive definitions)
Methodological detailsdevelopment and validation, training, test and external validation sets, gradient boosting predictor selection, logistic regression-based scoring systems
- Development and validation
- Training, test and external validation sets
- Gradient boosting predictor selection
- Logistic regression-based scoring systems
Performance
As reported in the abstract
Identification of LN
| Test or model | AUC (inclusive definition) | AUC | Sensitivity | Sensitivity (inclusive definition) | Sensitivity (strict definition) | Specificity |
|---|---|---|---|---|---|---|
| LN diagnosis codes | — not stated in the abstract | — not stated in the abstract | 43-73% | — not stated in the abstract | — not stated in the abstract | 92-97% |
| LN-Code | 0.93 | — not stated in the abstract | — not stated in the abstract | 0.88 | — not stated in the abstract | — not stated in the abstract |
| LN-No Code | — not stated in the abstract | 0.91 | 0.95 | — not stated in the abstract | 0.97 | — not stated in the abstract |
AUC (inclusive definition)
LN diagnosis codes— not stated in the abstract
LN-Code0.93
LN-No Code— not stated in the abstract
AUC
LN diagnosis codes— not stated in the abstract
LN-Code— not stated in the abstract
LN-No Code0.91
Sensitivity
LN diagnosis codes43-73%
LN-Code— not stated in the abstract
LN-No Code0.95
Sensitivity (inclusive definition)
LN diagnosis codes— not stated in the abstract
LN-Code0.88
LN-No Code— not stated in the abstract
Sensitivity (strict definition)
LN diagnosis codes— not stated in the abstract
LN-Code— not stated in the abstract
LN-No Code0.97
Specificity
LN diagnosis codes92-97%
LN-Code— not stated in the abstract
LN-No Code— not stated in the abstract
— not stated in the abstract
Original publication
Development and validation of a risk scoring system to identify patients with lupus nephritis in electronic health record data. Lupus Sci Med. Published 20 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →