Lupus & antiphospholipid syndrome
Comparison of late-onset and non-late-onset systemic lupus erythematosus individuals in a real-world electronic health record cohort
Authors' conclusion
LO-SLE individuals may be less likely to fit an expected course for SLE with less frequent positive autoantibodies at diagnosis and lower rates of nephritis, even after adjusting for race.
Study context
- Population
- Individuals with SLE in a large electronic health record (EHR)-based cohort
- Participants
- 123 vs 402
- Exposure
- Late-onset SLE vs non-late-onset SLE
- Late-onset systemic lupus erythematosus (LO-SLE)n = 123
- NLO-SLEn = 402reference
- Outcome
- Demographics, disease characteristics, SLE-specific antibodies and medication prescribing
Methodological detailselectronic health record (EHR)-based cohort
- Electronic health record (EHR)-based cohort
Main finding
As reported in the abstract
- Median (IQR) age at SLE diagnosis: LO-SLE 60 (56-67) years vs NLO-SLE 28 (20-38) years
- Autoantibody positivity declined with increasing age at SLE diagnosis
Observational data: associations, not effects.
Further findings
Female
P = 0.10
White race
P = 0.005
Positive dsDNA
P = 0.001
Positive RNP
P = 0.02
SLE nephritis
P < 0.001
Antimalarials prescribed
P = 0.04
AZA prescribed
P = 0.002
MMF prescribed
P < 0.001
Belimumab prescribed
P = 0.02
Smith, SSA and SSB
- No differences in Smith, SSA, and SSB
Original publication
Comparison of late-onset and non-late-onset systemic lupus erythematosus individuals in a real-world electronic health record cohort. Lupus. Published 7 March 2024. doi:10.
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