Lupus & antiphospholipid syndrome
Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus
Authors' conclusion
This proof-of-concept study demonstrates that LC-QTOF/MS is a powerful tool that agnostically detects circulating exogenous compounds.
Study context
- Population
- Patients with prevalent systemic lupus erythematosus (SLE) and unaffected controls; plasma exogenous chemicals measured by LC-QTOF/MS2,737 features analysed
- Participants
- 285 vs 106
- Exposure
- Patients with prevalent SLE vs unaffected controls
- SLEn = 285
- Controlsn = 106reference
- Outcome
- Association of mass spectrometry feature abundances (features in ≥25% of samples, n = 2,737) with SLE status
Methodological detailspilot study, hypothesis-free (exposome) approach, LC-QTOF/MS, adjusted for age and sex
- Pilot study
- Hypothesis-free (exposome) approach
- LC-QTOF/MS
- Adjusted for age and sex
Main finding
As reported in the abstract
Features associated with SLE status
Features significantly associated with SLE status (Bonferroni P < 0.05)
30
Of these, features matched to chemical names (phthalate metabolites, a formetanate metabolite, eugenol)
7
Observational data: associations, not effects.
Further findings
Features associated with SLE phenotypes
- Unmatched features associated with history of LN (Bonferroni P < 0.05)
- 2
- Feature associated with anti-dsDNA antibody production (Bonferroni P < 0.05)
- 1
Features varying by self-reported race and ethnicity
- Features varying by race and ethnicity, incl. a polyfluoroalkyl substance (analysis of variance P < 1.69 × 10-5)
- 17
Features correlated with current medication use
- Antimalarials
- 11
- MMF
- 6
- Prednisone
- 29
Original publication
Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 7 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →