Lupus & antiphospholipid syndrome
Atherosclerotic Plaque Progression and Incident Cardiovascular Events in a 10‐Year Prospective Study of Patients With Systemic Lupus Erythematosus: The Impact of Persistent Cardiovascular Risk Factor Target Attainment and Sustained Definition of Remission in SLE (DORIS) Remission
Main finding · Carotid plaque progressionResult — go to the resultIncidence rate ratio 2.26Authors' conclusion
Patients with SLE experience a 2.3-fold higher 10-year atherosclerosis progression risk than HCs, mitigated by sustained CVRF control and prolonged clinical remission. Persistent triple aPL positivity is associated with increased incidence of CVD events.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and age/sex-matched healthy controls, 10-year follow-up738 carotid US measurements
- Exposure
- SLE vs age/sex-matched HCs
- Outcome
- New carotid plaque development (plaque progression) on carotid US
- Follow-up
- 3-, 7-, and 10-year follow-up
Methodological detailsage/sex-matched healthy controls, multivariate mixed-effects Poisson regression, univariate Cox regression
- Age/sex-matched healthy controls
- Multivariate mixed-effects Poisson regression
- Univariate Cox regression
Main finding
Carotid plaque progression · 10 years
Incidence rate ratio
2.26
P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
Events
| Outcome | SLE | HCs | P value |
|---|---|---|---|
| Incident cardiovascular events · 10 years | 8 | 1 | permutation-based log-rank P = 0.036 |
Plaque progression in SLE per each sustainedly attained cardiovascular risk factor (CVRF) target (BP, lipids, smoking, body weight, physical activity)
- IRR per sustainedly attained CVRF target (32% reduction), P = 0.004
- 0.68
Atherosclerosis progression in SLE with DORIS achievement ≥75% of follow-up
- IRR (43% decrease), P = 0.033
- 0.57
Incident cardiovascular events · 10 years
- Associated with persistent triple aPL positivity
Original publication
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