Lupus & antiphospholipid syndrome
Hormone levels of female patients with SLE after anti-CD19 chimeric antigen receptor (CAR) T-cell treatment do not indicate a signal of impaired ovarian reserve
Authors' conclusion
Anti-CD19 CAR T-cell therapy, including standard lymphodepletion, showed no signal of impaired ovarian reserve, as assessed by AMH and hormone profiles.
Study context
- Population
- Women with severe, treatment-refractory SLE receiving autologous anti-CD19 CAR T-cell therapy with standard lymphodepletion at two tertiary care centres; median age 27 years
- Participants
- 13 women
- Exposure
- Reproductive hormone levels at baseline vs 12 months after anti-CD19 CAR T-cell therapy
- Outcome
- Ovarian reserve (AMH)
- Follow-up
- 12 months
Methodological detailstwo-centre, paired statistical analyses, samples independent of menstrual cycle phase
- Two-centre
- Paired statistical analyses
- Samples independent of menstrual cycle phase
Main finding
As reported in the abstract
AMH, baseline vs 12 months after CAR T-cell therapy
Anti-Müllerian hormone (AMH) levels were stable (baseline vs 12 months, median [IQR])
1.54 ng/ml [IQR 0.64-3.15] vs 2.14 ng/ml [0.63-3.26]
P = 0.886
Observational data: associations, not effects.
Further findings
E2, baseline vs 12 months
- E2 showed substantial variability without significant longitudinal change
- 243 pmol/l [186-346] vs 484 pmol/l [277-829]; P = 0.339
Progesterone, baseline vs 12 months
- Progesterone showed substantial variability without significant longitudinal change
- 0.90 nmol/l [0.80-0.90] vs 1.80 nmol/l [0.90-3.40]; P = 0.054
Follicle-stimulating hormone (FSH), baseline vs 12 months
- FSH increased modestly without a concomitant decline in AMH
- 6.60 IU/l [4.00-7.90] vs 7.20 IU/l [4.50-9.90]; P = 0.033
Luteinizing hormone (LH), baseline vs 12 months
- LH remained stable
- 6.10 IU/l [5.10-12.90] vs 7.00 IU/l [5.00-12.90]; P = 0.946
Prolactin, baseline vs 12 months
- Prolactin remained stable
- 10.0 µg/l [8.0-10.0] vs 8.0 µg/l [5.0-9.0]; P = 0.123
Original publication
Hormone levels of female patients with SLE after anti-CD19 CAR T-cell treatment do not indicate a signal of impaired ovarian reserve. Rheumatology (Oxford). Published 12 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →